Nishi Padma is the story of three innocent souls who by circumstances come near each other and are bound by the thread of eternal love. Pushpa, a simple housewife from a village is thrown out of her house by her husband because she could not have a child. Dejected she comes to her own village and meets a crook who takes her to Calcutta to give her a job. There she is cheated by him and is forced to take shelter in prostitute quarters. Anang Babu, a rich man of the city is neglected by his ultra modern wife and has no place to go. One day while passing through the same locality he hears a song and is attracted by the beautiful voice. He meets Pushpa and both are tied to each other. Nandoo, a child who stays nearby, is always ill-treated by his step-mother. He comes in Pushpa's life and finds a mother in her. But fate had something else to offer. They are all separated but then fate reunites them after ages.